| | Proteolytic cleavage sites | IGFBP protease | Reference |
| | IGFBP-2 | | Met166-Gly167, Lys168-Gly169, Tyr103-Gly104, Leu152-Ala153, Arg156-Glu157, Gln165-Met166, Thr205-Met206, Arg287-Met288 | Unknown protease in hemofiltrate | [80] | | Leu3-Phe4, Lys168-Gly169, Lys181-Leu182 | Unknown in milk | [200] | | Arg164-Gln165 | Human kallikrein-2 | [201] | | Leu152, Gly175-Leu176, Lys181-Leu182 | Matrix metalloproteinase-7 | [202] | | Gln165-Met166 | PAPP-A | [203] | | His165-Arg166 | Calpain | [204] |
| | IGFBP-3 | | Arg97-Ala98, Lys160-Val161 | Plasmin | [205] | | Arg95-Leu96, Lys160-Val16 | Plasmin | [206] | | Arg97-Ala98, Arg206-Gly207 | Thrombin | [205] | | Arg97-Ala98, Lys149-Lys150, Lys150-Gly151, Lys154-Asp155 | Serum | [205] | | Arg97-Ala98, Arg132-Val133, Tyr159-Lys160, Phe173-Ser174, Arg179-Glu180 | Seminal plasma PSA | [157] | | Arg97-Ala98, His131-Arg132, Tyr159-Lys160 | Urinary PSA | [207] | | Arg97-Ala98 | Cysteine protease from MCF-7 cells | [208] | | Tyr99-Leu100, Leu96-Arg97, Leu141-His142 | MMP-1, MMP-2 | [176] | | Tyr99-Leu100, Asn109-Ala110, Glu176-Ser177 | MMP-3 | [176] |
| | IGFBP-4 | | Lys120-His121 | Calcium-dependent serine protease from smooth muscle cells | [193, 209, 210] | | Met135-Lys136 | PAPP-A | [211, 212] |
| | IGFBP-5 | | Arg138-Arg139 | Serine protease from smooth muscle cells | [213] | | Ser143-Lys144 (secondary cleavage site), Ser143-Lys144 | PAPP-A2 | [214] | | Gln142-Ser-143 | PAPPA | [214] | | Lys120-His121, Arg156-Ile157, Arg192-Ala193 | Thrombin | [215] |
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