Research Article
Computational Analysis of the Binding Specificities of PH Domains
Table 3
Comparison of ligand-protein contacts in 5 PH domain-inositol phosphate complexes.
| | | Contact surface area (Å2) | Normalized complementarities | | | Legitimate contacts | Illegitimate contacts | Complementarities |
| 1B55 | P1-O3 | 31.3 | 10.6 | 20.7 | 0.17 | P3-O3 | 85.0 | 16.0 | 69.0 | 0.65 | P4-O3 | 86.8 | 17.9 | 68.9 | 0.76 | P5-O3 | 81.6 | 19.7 | 61.9 | 0.57 |
| 1FGY | P1-O3 | 31.0 | 23.8 | 7.2 | 0.06 | P3-O3 | 89.6 | 21.8 | 67.8 | 0.61 | P4-O3 | 114.8 | 8.5 | 106.3 | 1.00 | P5-O3 | 104.5 | 11.1 | 93.4 | 0.80 |
| 1MAI | P1-O3 | 44.0 | 0.5 | 43.5 | 0.34 | P4-O3 | 83.0 | 17.8 | 65.2 | 0.55 | P5-O3 | 85.8 | 0.3 | 85.5 | 0.72 |
| 1BTN | P1-O3 | 33.6 | 0 | 33.6 | 0.27 | P4-O3 | 69.4 | 23.5 | 45.9 | 0.43 | P5-O3 | 72.6 | 0 | 72.6 | 0.68 |
| 1FAO | P1-O3 | 34.8 | 18.1 | 16.7 | 0.13 | P3-O3 | 82.9 | 23.1 | 59.8 | 0.55 | P4-O3 | 102.1 | 3.1 | 99.0 | 0.98 | P5-O3 | 45.0 | 20.9 | 24.1 | 0.20 |
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