Analgesic Effect of Intra-Articular Injection of Temperature-Responsive Hydrogel Containing Bupivacaine on Osteoarthritic Pain in Rats

Figure 2

Effects of 0.5% bupivacaine on chronic arthritic pain induced by MIA. (a) Weight load and (b) mechanical allodynia were evaluated before and 30, 60, 90, 120, and 180 min after 0.5% bupivacaine or saline injection into the OA knee joint. Groups marked with asterisks (0.5% bupivacaine 20 μL) or number signs (0.5% bupivacaine 10 μL) indicate a statistically significantly difference from the saline group (, ).

(a)

(b)