Elevated Plasma Neutrophil Gelatinase-Associated Lipocalin Level as a Risk Factor for Anemia in Patients with Systemic Inflammation
Table 2
Plasma NGAL levels and hematologic parameters in patients with inflammation.
Patients with inflammation
NGAL > 156 ng/mL (n = 62)
NGAL ≤ 156 ng/mL (n = 125)
P value
NGAL
Plasma NGAL level (ng/mL)
269 (197–472)
84 (65–131)
<0.001
Hematologic parameters
Hemoglobin (g/dL)
10.9 ± 2.3
12.9 ± 2.5
<0.001
Anemia (n, %)
42 (67.7)
34 (27.2)
<0.001
Erythrocytes (×1012/L)
3.71 ± 0.69
4.16 ± 0.83
<0.001
Red cell distribution width (%)
14.5 ± 2.5
13.6 ± 2.1
0.017
Iron parameters
Serum iron (µg/dL)
27.4 ± 25.3
58.1 ± 43.5
<0.001
Transferrin saturation (%)
22.1 ± 18.6
29.0 ± 27.8
0.482
Serum ferritin (ng/mL)
342.9 (163.7–631.8)
196.4 (125.8–512.3)
0.376
Inflammation indices
hsCRP (mg/dL)
6.85 (3.74–12.06)
2.18 (0.86–4.15)
<0.001
cESR (mm/h)
47.5 ± 20.7
16.8 ± 13.2
<0.001
Data are expressed as median (interquartile range), mean ± SD, or frequency (%). NGAL, neutrophil gelatinase associated lipocalin; hsCRP, high-sensitivity C-reactive protein; cESR, corrected erythrocyte sedimentation rate.
