Elevated Plasma Neutrophil Gelatinase-Associated Lipocalin Level as a Risk Factor for Anemia in Patients with Systemic Inflammation
Table 3
Indices of anemia in patients with active and nonactive inflammation.
Patients with inflammation
Active inflammation (inflammation index > 1.0; n = 145)
Nonactive inflammation (inflammation index ≤ 1.0; n = 42)
P value
NGAL (ng/mL)
102 (68–197)
68 (55–83)
<0.001
Inflammation indices
hsCRP (mg/dL)
1.65 (0.15–5.90)
0.11 (0.05–0.19)
<0.001
cESR (mm/h)
22.7 ± 16.7
5.3 ± 4.7
<0.001
Renal parameters
eGFR (mL/min/1.73 m2)
85.3 ± 23.5
92.5 ± 14.3
<0.001
Serum creatinine (mg/dL)
0.90 ± 0.16
0.86 ± 0.15
0.001
Hematologic parameters
Hemoglobin (g/dL)
12.3 ± 2.2
13.2 ± 2.4
<0.001
Anemia (n, %)
65 (44.8)
11 (26.2)
<0.001
Erythrocytes (×1012/L)
4.04 ± 0.69
4.31 ± 0.71
<0.001
Red cell distribution width (%)
13.7 ± 2.0
13.2 ± 1.9
0.018
Data are expressed as median (interquartile range), mean ± SD, or frequency (%). NGAL, neutrophil gelatinase associated lipocalin; hsCRP, high-sensitivity C-reactive protein; cESR, corrected erythrocyte sedimentation rate; eGFR, estimated glomerular filtration rate.
