miR-1929-3p Overexpression Alleviates Murine Cytomegalovirus-Induced Hypertensive Myocardial Remodeling by Suppressing Ednra/NLRP3 Inflammasome Activation

Figure 3

miR-1929-3p overexpression relieved MCMV-induced myocardial remodeling in mice. (a) Schematic of intervention here and in Figures 4–7 in the experimental group. (b) The expression of miR-1929-3p in the myocardium. The value was normalized to the respective control groups, which was set to 1: (c) SBP; (d) DBP; (e) MAP; (f) HW/BW%; (g) LVW/BW%. (h) Representative images of H&E staining. (i) Quantitative analysis of the cell size (μm²) of cardiomyocytes in all groups. (j, k) qRT-PCR analysis of cardiac-specific fetal genes BNP and β-MHC. The value was normalized to the respective control groups, which was set to 1. (l) Representative images of Masson’s trichrome stain. (m) Quantitative analysis of fibrosis in all groups. The data are expressed as the (), vs. the age-matched control groups. , the MCMV+miR-1929-3p groups vs. the age-matched MCMV groups. Images were magnified to ×400 power; .

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