Research Article
KDM1A Identified as a Potential Oncogenic Driver and Prognostic Biomarker via Multi-Omics Analysis
Table 1
The summary of analysis on KDM1A expression and prognosis in different tumors of TCGA
| Tumor type | mRNA expression | Protein expression | Stage level | Poor prognosis of OS | Poor prognosis of DFS |
| ACC | Adrenocortical carcinoma | ns | NA | ns | Positive | Positive | BLCA | Bladder urothelial carcinoma | High | NA | ns | ns | ns | BRCA | Breast invasive carcinoma | High | High | ns | Negative | ns | CESC | Cervical squamous cell carcinoma and endocervical adenocarcinoma | High | NA | ns | ns | ns | CHOL | Cholangiocarcinoma | High | NA | ns | ns | ns | COAD | Colon adenocarcinoma | High | High | ns | Negative | ns | DLBC | Lymphoid neoplasm diffuse large B-cell lymphoma | High | NA | ns | ns | ns | ESCA | Esophageal carcinoma | High | NA | ns | ns | ns | GBM | Glioblastoma multiforme | High | NA | NA | ns | ns | HNSC | Head and neck squamous cell carcinoma | High | NA | F = 4.09 | ns | ns | KICH | Kidney chromophobe | Low | NA | ns | ns | Positive | KIRC | Kidney renal clear cell carcinoma | Low | High | ns | Negative | Negative | KIRP | Kidney renal papillary cell carcinoma | Low | NA | ns | ns | ns | LAML | Acute myeloid leukemia | Low | NA | NA | ns | ns | LGG | Brain lower grade glioma | ns | NA | NA | ns | Positive | LIHC | Liver hepatocellular carcinoma | High | NA | F = 4.3 | Positive | Positive | LUAD | Lung adenocarcinoma | High | High | ns | Positive | ns | LUSC | Lung squamous cell carcinoma | High | NA | ns | ns | ns | MESO | Mesothelioma | NA | NA | NA | ns | ns | OV | Ovarian serous cystadenocarcinoma | ns | High | F = 3.08 | Positive | ns | PAAD | Pancreatic adenocarcinoma | ns | NA | ns | ns | ns | PCPG | Pheochromocytoma and paraganglioma | ns | NA | NA | ns | ns | PRAD | Prostate adenocarcinoma | High | NA | NA | ns | ns | READ | Rectum adenocarcinoma | High | NA | ns | ns | ns | SARC | Sarcoma | ns | NA | NA | Positive | ns | SKCM | Skin cutaneous melanoma | ns | NA | F = 3.34 | ns | ns | STAD | Stomach adenocarcinoma | High | NA | ns | ns | ns | TGCT | Testicular germ cell tumors | ns | NA | ns | ns | ns | THCA | Thyroid carcinoma | ns | NA | ns | ns | ns | THYM | Thymoma | High | NA | NA | ns | ns | UCEC | Uterine corpus endometrial carcinoma | High | High | ns | ns | ns | UCS | Uterine carcinosarcoma | ns | NA | ns | ns | ns | UVM | Uveal melanoma | NA | NA | NA | ns | ns |
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OS, overall survival; DFS, disease-free survival; NA, not available; ns, no significance; < 0.05; < 0.01; < 0.001. |