Review Article
Cellular and Molecular Characteristics of Scarless versus Fibrotic Wound Healing
Table 2
Observed differences between fetal and adult fibroblasts.
| | Fetal Fibroblast | Adult Fibroblast |
| alpha-SMA (serum containing cultures) | Low | High |
| In-vitro collagen contraction | Less | More |
| Hyaluronic acid (HA) | Increased HA synthesis irrespective of cell density | Decreased HA synthesis as cell density increases | Hyaluronic acid receptor | High | Low |
| Proinflammatory cytokines | | | IL-6 | Low | High | IL-8 | Low | High |
| CCT-subunits | | | CCT-eta | Low | High | CCT-beta | No change | No change |
|
|