Dermatology Research and Practice

Research Article

Severe Cutaneous Adverse Drug Reactions at a Tertiary Care Center in Saudi Arabia

Table 2

Culprit medications for each type of severe cutaneous adverse drug reaction (n = 43).
 DRESSSJS/TENAGEP
n%n%n%
Vancomycin730.4    
Piperacillin/tazobactam28.7436.4342.9
Meropenem28.7327.3114.3
Sulfamethoxazole/trimethoprim14.419.1  
Amoxicillin    114.3
Ceftriaxone14.4    
Ciprofloxacin14.4    
Azithromycin    114.3
Metronidazole    114.3
Phenytoin417.4218.2  
Phenobarbital  19.1  
Carbamazepine14.4    
Lamotrigine28.7    
Allopurinol14.4    
Esomeprazole14.4    
Furosemide    114.3
Pembrolizumab  19.1  
AGEP, acute generalized exanthematous pustulosis; DRESS, drug reaction with eosinophilia and systemic symptoms; SJS/TEN, Stevens–Johnson syndrome/toxic epidermal necrolysis. Two patents had two culprit medications. Phenytoin and phenobarbital in the patient with DRESS-TEN overlap. Piperacillin/tazobactam and azithromycin in a patient with AGEP. The percentage of the most common culprit medication for each severe cutaneous adverse drug reaction is in bold.