Research Article

Antiangiogenic Activity and Pharmacogenomics of Medicinal Plants from Traditional Korean Medicine

Table 1

Korean plants with antiangiogenic potential.

Reference numberPlant species (and family)Traditional usesPart used Previously reported activity Reported chemical constituents

PB3699.1Acer mono Maxim.Leaves are an irritant and bark is astringent [28]LeavesThe sap increases calcium ion absorption in mouse [29] 5-O-methyl-(E)-resveratrol 3-O-β-D-glucopyranoside; 5-O-methyl-(E)-resveratrol 3-O-β-D-apiofuranosyl-(1 6)-β-D-glucopyranoside; quercetin, quercitrin; eriodictyol; naringenin; eriodictyol-7-O-α-D-glucopyranoside; 5,7-dihydroxychromone 7-O-α-D-glucopyranoside; naringenin 7-O-α-D-glucopyranoside [30]

PB4737A.1Adenophora racemosa J. Lee and S. Lee (Campanulaceae)Whole plant

PB4338.1Caryopteris incana (Thunb.) Miq. (Verbenaceae)In China for the relief of colds, coughs, and rheumatic pains [36]Leaves and stemsAntioxidant and cytotoxic activity reported for plant constituents [37, 38]Incanone; suyiol [37]; incanoside; verbascoside, isoverbascoside, phlinoside A, 6-O-caffeoyl-beta-D-glucose; incanoside C, incanoside D and incanoside E; β-D-fructofuranosyl-α-D-(6-O-[E]-sinapoyl) glucopyranoside [38, 39]; 8-O-acetylharpagide; 6′-O-p-coumaroyl-8-O-acetylharpagide; (3R)-oct-1-en-3-ol O-α-L-arabinopyranosyl-(1′′→ 6′)-O-β-D-glucopyranoside; apigenin 7-O-neohesperidinoside; 6′-O-caffeoylarbutin; leucosceptoside A; phlinoside A; 6′-O-Caffeoyl-8-O-acetylharpagide; (3R)-Oct-1-en-3-ol O-β-D-glucopyranosyl-(1′′→2′)-O-β -D-glucopyranoside; (3R)-Oct-1-en-3-ol O-α-L-arabinopyranosyl- (1′′′→ 6′′)-O-β-D-glucopyranosyl-(1′′→2′)-O-β -D-glucopyranoside [40]

PB2906.2Cinnamomum japonicum Sieb. (Theaceae)Stems

PB3828.1Eurya japonica Thunb. (Theaceae)As an ornamental [41] Leavescyanidin 3-glucoside; Cyanidin 3-O-(6′′-O-(4′′′-O-acetyl-α-L-rhamnopyranosyl)-B-D-glucopyranoslde) [42]

PB2552.1Reynoutria sachaliensis (F. Schmidt) Nakai.(Polygonaceae)Crops protection against phytopathogenic fungi [43]FruitsAntioxidant activity [44]Emodin; emodin-8-O-β-D-glucopyranoside; physcion-8-O-beta-D-glucopyranoside; quercetin-3-O-alpha-L-arabinofuranoside; quercetin-3-O-beta-D-galactopyranoside; quercetin-3-O-beta-D-glucuronopyranoside; anthraquinones, stilbenes [44]

PB2892.1Schisandra chinensis (Turcz.) Bail. (Magnoliaceae)Protective effect against deficits of the lung, liver, and gall bladder, alleviate cough and satisfy thirst [45]StemsAntihepatotoxic [46], enhance hepatic glutathione regeneration capacity [47], anti-inflammatory [45] Lignans (schizandrin; gamma-schizandrin; gomisins A, B, C, D, E and F); nortriterpenoids (pre-schsanartanin and schindilactones A–C; schintrilactones A and B; wuweizidilactones A–F) [46]

(—): not reported. The complete list of the tested plants is available in supporting information.