Antiangiogenic Activity and Pharmacogenomics of Medicinal Plants from Traditional Korean Medicine

Table 3

Separation of clusters of the NCI cancer cell lines obtained by hierarchical cluster analysis for selected phytochemicals from antiangiogenic plants derived from traditional Korean medicine. The log₁₀ IC₅₀ median values (M) of each compound were used as cutoff values to define cell lines as being sensitive or resistant. 𝑃>0.05 was considered as not significant (𝜒² test).

Compounds	Clusters	Sensitive	Resistant	P-value (𝜒^2 test)
Verbascoside	Partition*	≤−4.278	>−4.278	𝑃=3.35497×10^−4
	Cluster 1	3	14
	Cluster 2	4	9
	Cluster 3	9	1
	Cluster 4	8	1
Emodin	Partition*	≤−4.607	>−4.607	𝑃=0.0142
	Cluster 1	7	2
	Cluster 2	5	1
	Cluster 3	8	15
	Cluster 4	8	4
	Cluster 5	1	6
Apigenin	Partition*	≤−4.543	>−4.543	𝑃=0.02628
	Cluster 1	2	9
	Cluster 2	5	4
	Cluster 3	9	1
	Cluster 4	6	7
Eriodictyol tetraacetate	Partition	≤−4.358	>−4.358	n.s.**
	Cluster 1, 2, 3	6	2
	Cluster 4	2	5
Resveratrol	Partition*	≤−4.223	>−4.223	n.s.**
	Cluster 1	3	2
	Cluster 2	9	5
	Cluster 3	5	4
	Cluster 4	3	10
	Cluster 5	4	3
Axitinib (control drug)	Partition*	<−5.015	>−5.015	n.s.**
	Cluster 1	10	15
	Cluster 2	4	6
	Cluster 3	15	8

∗log₁₀ IC₅₀ (M).
∗∗n.s.: not significant (𝑃>0.05).