Review Article
Recombinant Protein Production of Earthworm Lumbrokinase for Potential Antithrombotic Application
Table 1
Lumbrokinase gene clones, expression, and characterization.
| Earthworm | Lumbrokinase | GenBank no. | Expression host(s) | Characterization references |
| L. bimastus | PI239 | AF433650 | P. pastoris E. coli | Ge et al., 2005 [22] Xu et al., 2010 [23] | PM246 | AY187629 | P. pastoris |
Hu et al., 2005 [21] | PV242 | AF109648 | E. coli | Xu et al., 2002 [17] |
| L. rubellus | F-III-1 | AB045720 | | | F-III-2 | AB045719 | P. pastoris E. coli | Sugimoto and Nakajima 2001 [24] Li et al., 2008 [25] | 1T4 | U25643 | | | lk-6 (F6) | AF304199 | E. coli | Cho et al., 2004 [26] | EFE3-1 |
U25648 (AY327442)* | Goat mammary glands Sunflower plant | Hu et al., 2004 [20] Guan et al., 2013 [27] |
| E. fetida | CST1 | AY840996 | E. coli | Li et al., 2012 [15] | CST2-2 | AY684712 | | | CST2-1 | AY684711 | | | TFe | EU167737 | | | Tfd | EU167736 | | | Tfc | EU167735 | | | Tf2 | EU167734 | | | F238 | DQ202401 | P. pastoris | Zhao et al., 2006 [28] | efp-1 | DQ418454 | | | efp-0 | DQ836917 | | | a1 | AF393512 | | | EFE-3 | AY438622 | E. coli P. pastoris | Dong et al., 2004 [29] Yuan et al., 2006 [30] | | AF432224 | | | | AY438624 | | | | AY438623 | | | | AY438625 | | |
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(AY327442) was codon optimized from U25648.
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