Homotherapy for Heteropathy: A Molecular Mechanism of Poria Sini Decoction for Treatment of Liver Cancer and Chronic Heart Failure

Table 2

Experimental verification results of main chemical constituents.

Active ingredient	Disease	Treatment mechanism	Experiment model	Literature
Naringenin	LC	Naringenin induces growth inhibition, cell cycle arrest, and apoptosis in human hepatocellular carcinoma cells	Cell culture	[23]
Naringenin	CHF	Naringenin attenuates pressure overload-induced cardiac hypertrophy	Mice	[24]
Isorhamnetin	LC	Isorhamnetin induces ROS-dependent cycle arrest at G2/M phase and apoptosis in human hepatocarcinoma Hep3B cells	Cell experiment	[25]
Isorhamnetin	CHF	Isorhamnetin exerts a protective effect against myocardial injury through the attenuation of apoptosis	Cell culture	[26]
			Living organisms
Calycosin	LC	Calycosin has a potential effect in inhibiting oncogene expression and increasing anticancer genes expression	Cell culture	[27]
Calycosin	CHF	Calycosin inhibited inflammation and fibrosis via activation of the PI3K-AKT pathway in postacute myocardial infarction rats	The rat	[28]

Note. LC: liver cancer; CHF: chronic heart failure.