Tissue Regeneration in Dentistry
1Department of Orthodontics and Craniofacial Developmental Biology, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima 734-8553, Japan
2Department of Orthodontics and Pediatric Dentistry, Center for Organogenesis, Center for Computational Medicine and Bioinformatics, Schools of Dentistry and Medicine, University of Michigan, Ann Arbor, MI, 48109, USA
3Tissue Engineering and Regenerative Medicine (TERM) Laboratory, Second University of Naples, 5 Via L. Armanni, 80138 Naples, Italy
4Department of Orthodontics, Hiroshima University Hospital, Hiroshima 734-8553, Japan
5Division of Pulp Biology, Operative Dentistry, and Endodontics, Department of Cariology and Periodontology, Kyushu Dental College, Kitakyushu, Japan
Tissue Regeneration in Dentistry
Description
Previously, for the treatment of tissue defect, autogenous tissue grafts or various biomaterials were used for the transplantation to fulfill the defect. However, various shortcomings have been pointed out: substantial surgical invasion, reduced quality of life, lower success rate, less biocompatibility of artificial materials, and so on. Under such background, various studies for tissue engineering have recently been conducted to explore a new era of tissue defect treatment. In these studies, for the success in tissue engineering, three essential factors were examined successfully, that is, cells to be transplanted, signaling molecules, and scaffold. Currently, undifferentiated mesenchymal stem cells (MSCs) and dental tissues stem cells or their differentiated forms are transplanted with the appropriate scaffolds, producing excellent tissue regeneration. In addition, such signaling molecules as basic FGF, BDNF, BMP, and TGF-beta are demonstrated to induce new tissue formation. We invite authors to submit original research and review articles that seek the nature of tissue regeneration and the above-mentioned three factors. We are thus interested in articles that explore in vitro and in vivo aspects of tissue regeneration which is applicable to dentistry. Potential topics include, but are not limited to:
- Proliferation and differentiation of MSCs or dental stem cells and the relevant factors
- Cellular responses to various signaling molecules
- Cellular responses to artificial biomaterials to be used as scaffolds
- Animal models for the experiment of tissue engineering
- In vivo studies for tissue regeneration in artificially created tissue defects
- Confirmation for the safety of tissue regeneration
- Ethical consideration for tissue engineering
Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/ijd/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/ according to the following timetable: