The Oncogenic Role of KLF7 in Colon Adenocarcinoma and Therapeutic Perspectives

Figure 3

Functional effects of KLF7 knockdown in colon adenocarcinoma. (a) Western blot analysis confirmed the effective knockdown of KLF7 using specific shRNAs compared to the control scrambled shRNA in HCT116 and SW480 cell lines. (b) The CCK-8 assay demonstrated that silencing KLF7 resulted in a significant decrease in cell proliferation in colon adenocarcinoma cells. (c) Xenograft growth curves revealed a notable reduction in the growth rate of KLF7-knockout COAD cell-derived xenografts compared to control COAD cell-derived xenografts.

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