International Journal of Genomics

Research Article

Transcription Analysis of the THBS2 Gene through Regulation by Potential Noncoding Diagnostic Biomarkers and Oncogenes of Gastric Cancer in the ECM-Receptor Interaction Signaling Pathway: Integrated System Biology and Experimental Investigation

Table 5

Gene ontology analysis of THBS2 and related proteins, based on enrichr database.
Gene ontology
TermAdjusted valueGenes
Cellular component
Collagen-containing extracellular matrix (GO:0062023)0.028067617ADAMTS1, MMP2, THBS2
Molecular function
Metalloendopeptidase activity (GO:0004222)ADAMTSL1, ADAMTS5, ADAMTS2, ADAMTS1, MMP2, ADAMTS12
Metallopeptidase activity (GO:0008237)ADAMTSL1, ADAMTS5, ADAMTS2, ADAMTS1, MMP2, ADAMTS12
Endopeptidase activity (GO:0004175)ADAMTSL1, ADAMTS5, ADAMTS2, ADAMTS1, MMP2, ADAMTS12
C-X3-C chemokine binding (GO:0019960)0.013186586ITGB1
Collagen binding involved in cell-matrix adhesion (GO:0098639)0.013186586ITGB1
Cell-matrix adhesion mediator activity (GO:0098634)0.015376688ITGB1
Clathrin heavy chain binding (GO:0032050)0.016462703LRP1
Protein binding involved in heterotypic cell-cell adhesion (GO:0086080)0.016462703CD47
Cell adhesion mediator activity (GO:0098631)0.034997935CD47
Lipoprotein particle receptor binding (GO:0070325)0.036711163LRP1
Chemokine binding (GO:0019956)0.038103413ITGB1
Cell-cell adhesion mediator activity (GO:0098632)0.045728931CD47
Biological process
Extracellular structure organization (GO:0043062)ITGB1, ADAMTSL1, ADAMTS5, ADAMTS2, ADAMTS1, MMP2, CD47, ADAMTS12
External encapsulating structure organization (GO:0045229)ITGB1, ADAMTSL1, ADAMTS5, ADAMTS2, ADAMTS1, MMP2, CD47, ADAMTS12
Extracellular matrix organization (GO:0030198)ITGB1, ADAMTSL1, ADAMTS5, ADAMTS2, ADAMTS1, MMP2, CD47, ADAMTS12
Integrin-mediated signaling pathway (GO:0007229)ITGB1, ADAMTS1, CD47
Positive regulation of vascular-associated smooth muscle cell proliferation (GO:1904707)0.002549534ADAMTS1, MMP2
Cellular response to cytokine stimulus (GO:0071345)0.003555608ITGB1, MMP2, CD47, ADAMTS12
Regulation of angiogenesis (GO:0045765)0.005029385ITGB1, ADAMTS1, THBS2
Regulation of vascular-associated smooth muscle cell proliferation (GO:1904705)0.005029385ADAMTS1, MMP2