OSM May Serve as a Biomarker of Poor Prognosis in Clear Cell Renal Cell Carcinoma and Promote Tumor Cell Invasion and Migration

Table 3

Univariate and multivariate Cox analyses of OSM in ccRCC.

Characteristics	Total ()	HR (95% CI) univariate analysis	value univariate analysis	HR (95% CI) multivariate analysis	value multivariate analysis
Pathologic T stage	530
T1+2	340	Reference		Reference
T3+4	190	3.321 (2.356-4.681)	<0.001	0.412 (0.103-1.642)	0.209
Pathologic N stage	255
N0	239	Reference		Reference
N1	16	3.422 (1.817-6.446)	<0.001	1.364 (0.447-4.160)	0.586
Pathologic M stage	498
M0	420	Reference		Reference
M1	78	4.401 (3.226-6.002)	<0.001	0.433 (0.040-4.726)	0.493
Pathologic stage	527
Stage I-II	322	Reference		Reference
Stage III-IV	205	2.649 (1.767-3.971)	<0.001	3.962 (0.927-16.926)	0.063
Histologic grade	522
G1-2	241	Reference		Reference
G3-4	281	2.253 (1.835-2.766)	<0.001	1.528 (1.210-1.929)	<0.001
Age	530
≤60	264	Reference		Reference
>60	266	1.791 (1.319-2.432)	<0.001	1.595 (1.030-2.470)	0.037
Gender	530
Female	187	Reference
Male	354	0.924 (0.679-1.257)	0.613
OSM	530
Low	265	Reference		Reference
High	265	1.607 (1.185-2.178)	0.002	1.717 (1.094-2.695)	0.019