OMICS Approaches Evaluating Keloid and Hypertrophic Scars

Table 4

Transcriptomic study of differentially regulated genes in keloids, hypertrophic scars, and normal skin.

Gene	Keloids	Hypertrophic scars	Normal skin
−1 chain of collagen XI	↑ [62]	⟶
α − 2 chain of collagen type 5	↑ [62]	⟶
Pro (α − 1) chain of collagen type 3	↑ [62]	⟶
Pro (α − 2) chain of collagen type 1	↑ [62]	⟶
α − 1 chain of collagen type 4	↑ [62]	⟶
Fibronectin	↑ [62]	⟶
Nerve growth factor (NGF)	↑ [62]	⟶
TGF-β1	↑ [62]	⟶
VEGF165 receptor	↓ [62]	͢
ASK1		⟶	↑ compared to KL
KIAA0018		⟶	↑ compared to KL
p21		⟶	↓ compared to KL
ACAN	↑ [63]	⟶
COL1A1	↑ [63]	⟶
COL1A2	↑ [63]	⟶
COL4A2	↑ [63]	⟶
COL5A2	↑ [63]	⟶
COL6A1	↑ [63]	⟶
COL15A1	↑ [63]	⟶
FN1	↑ [63]	⟶
OGN	↑ [63]	⟶
POSTN	↑ [63]	⟶
TGF-βriii	↓ [63]	⟶
VCAN	↑ [63]	⟶
ANXA1	↑ [63]	⟶
EGFR	↓ [63]	⟶
HIF-1A	↑ [63]	⟶
SERPINF1	↓ [63]	⟶
CNR1	↓ [64]	⟶
HOXA5, HOXA7, HOXC11	↓ [64]	⟶
HIST1H1A, HIST1H1B, HIST1H2BH, and HIST1H4F	↑ [64]	⟶
ASF1B	↑ [64]	⟶
Proteins K and H	↑ [64]	⟶
HAS2	↑ [64]	⟶
KRT7	↑ [64]	⟶
LOXL2	↑ [64]	⟶
KRT1	↓ [64]	⟶
KRT16	↓ [64]	⟶
CDH11	↑ [64]	⟶
VIM	↑ [64]	⟶
α-smooth muscle actin	⟶	↑ [65]
Tropomyosin TM30	⟶	↑ [65]
Vimentin	⟶	↑ [65]
Profilin	⟶	↑ [65]
BM40	⟶	↑ [65]
Quinoline phosphoribosyltransferase	⟶	↑ [66]
Serine (or cysteine) proteinase inhibitor clade B	⟶	↑ [66]
Collagen type XIII α − 1	⟶	↑ [66]
Plasminogen activator urokinase	⟶	↑ [66]
Neuromedin	⟶	↑ [66]
Stromal cell derived factor −1, serine protease 23	⟶	↓ [66]
Pregnancy specific β glycoprotein 7	⟶	↓ [66]
Tubulin-α − 1	⟶	↓ [66]
Cardiac actin gene	⟶	↓ [66]