Differentially Expressed Genes Analysis in the Human Small Airway Epithelium of Healthy Smokers Shows Potential Risks of Disease Caused by Oxidative Stress and Inflammation and the Potentiality of Astaxanthin as an Anti-Inflammatory Agent
Table 3
Gene annotation function (GO biological process) related to Nrf2 on the central cluster C1, C2, C3, and C4.
Term
value
Adjusted value
Genes
C1
Cellular response to chemical stress (GO:0062197)
2.119E − 08
3.68706E − 06
GPX3; PRDX1; SOD1; NFE2L2
Cellular response to oxidative stress (GO:0034599)
5.01528E − 08
4.36329E − 06
GPX3; PRDX1; SOD1; NFE2L2
Hydrogen peroxide metabolic process (GO:0042743)
9.55463E − 08
5.54169E − 06
GPX3; PRDX1; SOD1
Removal of superoxide radicals (GO:0019430)
4.7186E − 06
0.000200665
PRDX1; SOD1
Cellular response to superoxide (GO:0071451)
5.76623E − 06
0.000200665
PRDX1; SOD1
Regulation of an oxidative stress-induced intrinsic apoptotic signaling pathway (GO:1902175)
1.60221E − 05
0.00046464
SOD1; NFE2L2
Hydrogen peroxide catabolic process (GO:0042744)
2.19802E − 05
0.000546364
GPX3; PRDX1
Superoxide metabolic process (GO:0006801)
5.18203E − 05
0.001127092
PRDX1; SOD1
Retina homeostasis (GO:0001895)
6.57764E − 05
0.001271677
PRDX1; SOD1
Positive regulation of intrinsic apoptotic signaling pathway (GO:2001244)
8.13833E − 05
0.001416069
BECN1; SOD1
C2
Negative regulation of signal transduction in absence of ligand (GO:1901099)
2.64721E − 05
0.004729029
CSF2; IL1B
Negative regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001240)
2.64721E − 05
0.004729029
CSF2; IL1B
Regulation of an extrinsic apoptotic signaling pathway in absence of ligand (GO:2001239)
3.95183E − 05
0.004729029
CSF2; IL1B
Response to organic cyclic compound (GO:0014070)
0.000184064
0.016519707
IL1B; SPP1
Regulation of T cell proliferation (GO:0042129)
0.000295584
0.016860769
ARG1; IL1B
Negative regulation of extrinsic apoptotic signaling pathway (GO:2001237)
0.000327517
0.016860769
CSF2; IL1B
Positive regulation of transport (GO:0051050)
0.000423647
0.016860769
IL1B; BAX
Neutrophil degranulation (GO:0043312)
0.000450176
0.016860769
ARG1; CYBB; CTSS
Neutrophil activation is involved in immune response (GO:0002283)
0.000461244
0.016860769
ARG1; CYBB; CTSS
Neutrophil mediated immunity (GO:0002446)
0.000469659
0.016860769
ARG1; CYBB; CTSS
C3
Aggrephagy (GO:0035973)
2.02451E − 05
0.001871553
UBB; HDAC6
Positive regulation of transcription by RNA polymerase II (GO:0045944)
2.03436E − 05
0.001871553
HDAC2; UBB; GATA4; FOXO3
Negative regulation of transcription, DNA-templated (GO:0045892)
2.41389E − 05
0.001871553
HDAC2; UBB; FOXO3; HDAC6
Positive regulation of programmed cell death (GO:0043068)
2.8328E − 05
0.001871553
UBB; FOXO3; HDAC6
Positive regulation of signaling receptor activity (GO:2000273)
3.31836E − 05
0.001871553
HDAC2; HDAC6
Protein deacetylation (GO:0006476)
4.92876E − 05
0.002045828
HDAC2; HDAC6
Histone deacetylation (GO:0016575)
5.38074E − 05
0.002045828
HDAC2; HDAC6
Positive regulation of transcription, DNA-templated (GO:0045893)
5.80377E − 05
0.002045828
HDAC2; UBB; GATA4; FOXO3
Regulation of proteolysis (GO:0030162)
7.11791E − 05
0.002230277
HDAC2; HDAC6
Selective autophagy (GO:0061912)
8.5064E − 05
0.002398805
UBB; HDAC6
C4
Aerobic electron transport chain (GO:0019646)
1.63813E − 07
5.13101E − 07
UQCRC2; COX5B; COX5A
Mitochondrial ATP synthesis coupled electron transport (GO:0042775)
1.71034E − 07
5.13101E − 07
UQCRC2; COX5B; COX5A
Mitochondrial electron transport, cytochrome c to oxygen (GO:0006123)
4.07582E − 06
8.15165E − 06
COX5B; COX5A
Mitochondrial electron transport, ubiquinol to cytochrome c (GO:0006122)
