International Journal of Inflammation / 2023 / Article / Tab 4 / Research Article
Differentially Expressed Genes Analysis in the Human Small Airway Epithelium of Healthy Smokers Shows Potential Risks of Disease Caused by Oxidative Stress and Inflammation and the Potentiality of Astaxanthin as an Anti-Inflammatory Agent Table 4 Relationship between smoking-related diseases with C1, C2, C3, and C4 clusters. Data obtained from CTD (
https://ctdbase.org/ ) [
16 ].
Disease name Disease ID Disease categories Genes Chronic bronchitis MESH: D029481 Pathology (process)|respiratory tract disease SPP1; TKT; PRDX1; BECN1; CYBB; ND6; COX5B; GPX3; UQCRC2; HDAC6; FOXO3; GATA4; IL1B; SKAP2; HDAC2; IDH1; SOD1; CTSS; BAX; COX5A; CSF2; UBB; ARG1 Adenocarcinoma of lung MESH: D000077192 Cancer SPP1; TKT; PRDX1; BECN1; CYBB; ND6; COX5B; GPX3; UQCRC2; HDAC6; FOXO3; GATA4; IL1B; SKAP2; HDAC2; IDH1; SOD1; CTSS; BAX; COX5A; CSF2; UBB; ARG1 Non-small-cell lung carcinoma MESH: D002289 Cancer|respiratory tract disease SPP1; TKT; PRDX1; BECN1; CYBB; ND6; COX5B; GPX3; UQCRC2; HDAC6; FOXO3; GATA4; IL1B; SKAP2; HDAC2; IDH1; SOD1; CTSS; BAX; COX5A; CSF2; UBB; ARG1 Small cell lung carcinoma MESH: D055752 Cancer|respiratory tract disease SPP1; TKT; PRDX1; BECN1; CYBB; ND6; COX5B; GPX3; UQCRC2; HDAC6; FOXO3; GATA4; IL1B; SKAP2; HDAC2; IDH1; SOD1; CTSS; BAX; COX5A; CSF2; UBB; ARG1 Type 2 diabetes mellitus MESH: D003924 Endocrine system disease|metabolic disease SPP1; TKT; PRDX1; BECN1; CYBB; ND6; COX5B; GPX3; UQCRC2; HDAC6; FOXO3; GATA4; IL1B; SKAP2; HDAC2; IDH1; SOD1; CTSS; BAX; COX5A; CSF2; UBB; ARG1 Emphysema MESH: D004646 Pathology (process) SPP1; TKT; PRDX1; BECN1; CYBB; ND6; COX5B; GPX3; UQCRC2; HDAC6; FOXO3; GATA4; IL1B; SKAP2; HDAC2; IDH1; SOD1; CTSS; BAX; COX5A; CSF2; UBB; ARG1 Ischemic stroke MESH: D000083242 Cardiovascular disease|nervous system disease SPP1; TKT; PRDX1; BECN1; CYBB; ND6; COX5B; GPX3; UQCRC2; HDAC6; FOXO3; GATA4; IL1B; SKAP2; HDAC2; IDH1; SOD1; CTSS; BAX; COX5A; CSF2; UBB; ARG1 Lung diseases MESH: D008171 Respiratory tract disease SPP1; TKT; PRDX1; BECN1; CYBB; ND6; COX5B; GPX3; UQCRC2; HDAC6; FOXO3; GATA4; IL1B; SKAP2; HDAC2; IDH1; SOD1; CTSS; BAX; COX5A; CSF2; UBB; ARG1 Pulmonary heart disease MESH: D011660 Cardiovascular disease SPP1; BECN1; CYBB; ND6; COX5B; GPX3; UQCRC2; HDAC6; FOXO3; GATA4; IL1B; IDH1; SOD1; CTSS; BAX; COX5A; CSF2; UBB; ARG1 Inflammation MESH: D007249 Pathology (process) SPP1; TKT; PRDX1; BECN1; CYBB; ND6; COX5B; GPX3; UQCRC2; HDAC6; FOXO3; GATA4; IL1B; SKAP2; HDAC2; IDH1; SOD1; CTSS; BAX; COX5A; CSF2; UBB; ARG1
