N-Acetylcysteine Decreases Myocardial Content of Inflammatory Mediators Preventing the Development of Inflammation State and Oxidative Stress in Rats Subjected to a High-Fat Diet

Figure 4

The concentration of arachidonic acid derivatives, i.e., (a) prostaglandin E2 (PGE2), (b) prostaglandin I2 (PGI2), (c) leukotriene B4 (LTB4), (d) leukotriene C4 (LTC4), and (e) lipoxin A4 (LXA4) after eight-week N-acetylcysteine (NAC) treatment in the left ventricle tissue of rats fed a standard diet (control) or a high-fat diet (HFD). The eicosanoids content was examined by the enzyme-linked immunosorbent assay (ELISA) kits. The data are expressed as mean ± standard deviation (SD) and based on ten independent determinations (n = 10). The significant differences were assessed by two-way ANOVA followed by a respective post hoc test (Tukey’s test and t-test). , significant difference compared to the control group; ^#, significant difference compared to the HFD group.

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