N-Acetylcysteine Decreases Myocardial Content of Inflammatory Mediators Preventing the Development of Inflammation State and Oxidative Stress in Rats Subjected to a High-Fat Diet

Figure 6

The concentration of antioxidative and oxidative parameters, i.e., (a) superoxide dismutase 2 (SOD2), (b) catalase (CAT), (c) reduced glutathione (GSH), (d) 4-hydroxynonenal (4-HNE), (e) malondialdehyde (MDA), and (f) advanced glycation end products (AGE) after eight-week N-acetylcysteine (NAC) treatment in the left ventricle tissue of rats fed a standard diet (control) or a high-fat diet (HFD). The content of oxidative balance parameters was examined by the enzyme-linked immunosorbent assay (ELISA) and the colorimetric kits. The data are expressed as mean ± standard deviation (SD) and based on ten independent determinations (n = 10). The significant differences were assessed by two-way ANOVA followed by a respective post hoc test (Tukey’s test and t-test). , significant difference compared to the control group; ^#, significant difference compared to the HFD group.

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