Research Article
N-Acetylcysteine Decreases Myocardial Content of Inflammatory Mediators Preventing the Development of Inflammation State and Oxidative Stress in Rats Subjected to a High-Fat Diet
Table 3
The concentration of selected cytokines and chemokines, i.e., granulocyte colony-stimulating factor (G-CSF), granulocyte-macrophage colony-stimulating factor (GM-CSF), growth-regulated oncogenes/keratinocyte chemoattractant (GRO/KC), interferon γ (IFN-γ), interleukin 1α (IL-1α), interleukin 1β (IL-1β), interleukin 2 (IL-2), interleukin 4 (IL-4), interleukin 5 (IL-5), interleukin 6 (IL-6), interleukin 7 (IL-7), interleukin 10 (IL-10), interleukin 12 p70 (IL-12 p70), interleukin 13 (IL-13), interleukin 17A (IL-17A), interleukin 18 (IL-18), monocyte chemoattractant protein 1 (MCP-1), macrophage inflammatory protein 1α (MIP-1α), macrophage inflammatory protein 3α (MIP-3α), regulated upon activation, normal T-cell expressed and secreted (RANTES), tumor necrosis factor α (TNF-α), and vascular endothelial growth factor (VEGF) after eight-week N-acetylcysteine (NAC) treatment in the left ventricle tissue of rats fed a standard diet (control) or a high-fat diet (HFD). The cytokines and chemokines content was examined by the bio-plex immunoassay kit. The data are expressed in picograms per milliliter as the mean ± standard deviation (SD) and based on ten independent determinations (n = 10). The significant differences were assessed by two-way ANOVA followed by a respective post hoc test (Tukey’s test and t-test). , significant difference compared to the control group; #, significant difference compared to the HFD group.
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