In Vitro and In Vivo Anti-Inflammatory Properties of the Hydroethanolic Extract of the Roots of Vernonia guineensis (Asteraceae)

Table 2

Effect of hydroethanolic extract of V. guineensis on cyclooxygenase, 5-lipoxygenase, protein denaturation, proteanase, and membrane stabilisation.

	Concentration (µg/ml)	Inhibition (%)
		COX	5-LOX	Protein denaturation	Proteinase	Membrane stabilisation
Iburprofen	50	51.90 ± 1.29	43.02 ± 1.90	—	—	—
	100	63.10 ± 1.21	56.21 ± 0.76	—	—	—
	200	78.11 ± 0.33	66.34 ± 1.19	—	—	—
	400	82.21 ± 0.22	73.71 ± 1.01	—	—	—
Diclofenac	50	—	—	40.22 ± 0.89	52.55 ± 1.23	56.32 ± 1.34
	100	—	—	59.01 ± 1.21	68.03 ± 1.09	67.62 ± 0.29
	200	—	—	70. 32 ± 0.23	75.21 ± 1.92	73.01 ± 1.89
	400	—	—	83.88 ± 2.01	81.02 ± 1.12	83.90 ± 1.11
Hydroethanolic extract	50	50.10 ± 0.32	35.33 ± 0.21	44.51 ± 1.34	49.90 ± 1.22	46.52 ± 0.27
	100	62.19 ± 0.82	41.23 ± 0.39	59.20 ± 1.10	61.11 ± 2.01	59.99 ± 0.26
	200	73.29 ± 0.19	53.22 ± 0.98	67.01 ± 1.34	70.71 ± 1.01	73.27 ± 1.30
	400	80.19 ± 0.13	64.66 ± 1.11	79.02 ± 0.81	83. 88 ± 1.11	80.57 ± 1.02

The percentage values were obtained using various concentrations of test compounds and readings are presented as the mean of triplicates.