In Vitro and In Vivo Anti-Inflammatory Properties of the Hydroethanolic Extract of the Roots of Vernonia guineensis (Asteraceae)

Table 5

Effect of the hydroethanolic extract of V. guineensis on some serum parameters.

Treatment	Dose (mg/kg)	ALT (μ/I)	AST (μ/I)	ALP (μ/I)	Creatinine (mg/ml)	Protein (g/dl)
Normal control	—	119.30 ± 2.86	421.90 ± 18.65	226.80 ± 2.70	0.38 ± 0.03	6.76 ± 0.51
Negative control	—	205.10 ± 7.04^λ	464.70 ± 11.97	354.20 ± 5.79^λ	0.43 ± 0.08	3.76 ± 0.24^λ
Diclofenac	5	156.00 ± 5.37^βc	455.50 ± 12.15	328.10 ± 4.68^β	0.41 ± 0.06	5.31 ± 0.23
Hydroethanolic extract	62.5	207.60 ± 8.47^λ	462.40 ± 14.23	346.50 ± 15.33^λ	0.43 ± 0.05	3.96 ± 0.16^β
	125	150.00 ± 8.91^αc	454.30 ± 13.77	268.30 ± 25.81^a	0.39 ± 0.03	5.94 ± 0.33^b
	250	134.30 ± 3.46^c	439.20 ± 24.98	244.00 ± 5.63^b	0.38 ± 0.03	6.70 ± 0.27^b

Each value represents the mean ± SEM of 5 animals. ALP: alkaline phosphatase; AST: aminotransferase; ALT: alanine aminotransferase. ^a, ^b, and ^c are statistically significant compared to negative control; ^α, ^β, and ^λ are statistically significant compared to the neutral control.