The association between AIRE rs2075876 and the clinical parameters in the lupus patients.
Genotypes
Models
Alleles
Dominant
Recessive
AA ()
AG ()
GG ()
value
AA+AG ()
GG ()
value
OR (95% CI)
AA ()
GG+AG ()
value
OR (95% CI)
A
G
valve
OR (95% CI)
Constitutional, (%)
8 (72.7)
25 (69.4)
28 (53.8)
0.242
33 (70.2)
28 (53.8)
0.094
2.0 (0.9-4.6)
8 (72.7)
53 (60.2)
0.523
1.8 (0.4-7.1)
41 (70.7)
81 (57.9)
0.091
1.8 (1-3.4)
MC, (%)
8 (72.7)
32 (88.9)
40 (76.9)
0.289
40 (85.1)
40 (76.9)
0.302
1.7 (0.6-4.8)
8 (72.7)
72 (81.8)
0.437
0.6 (0.1-2.5)
48 (82.8)
112 (80)
0.654
1.2 (0.5-2.7)
MSK, (%)
11 (100)
35 (97.2)
42 (80.8)
0.025a
46 (97.9)
42 (80.8)
0.009
11 (1.3-89.2)
11 (100)
77 (87.5)
0.606
57 (98.3)
119 (85)
0.005
10.1 (1.3-76.6)
Serositis, (%)
3 (27.3)
20 (55.6)
26 (50)
0.258
23 (48.9)
26 (50)
0.916
1 (0.4-2.1)
3 (27.3)
46 (52.3)
0.200
0.3 (0.1-1.4)
26 (44.8)
72 (51.4)
0.398
0.8 (0.4-1.4)
Nephritis, (%)
11 (100)
26 (72.2)
35 (67.3)
0.086
37 (78.7)
35 (67.3)
0.203
1.8 (0.7-4.5)
11 (100)
61 (69.3)
0.032
48 (82.8)
96 (68.6)
0.041
2.2 (1-4.7)
Hematological, (%)
6 (54.5)
17 (47.2)
32 (61.5)
0.413
23 (48.9)
32 (61.5)
0.208
0.6 (0.3-1.3)
6 (54.5)
49 (55.7)
0.943
1 (0.3-3.4)
29 (50)
81 (57.9)
0.311
0.7 (0.4-1.3)
NPS, (%)
2 (18.2)
5 (13.9)
6 (11.5)
0.827
7 (14.9)
6 (11.5)
0.622
1.3 (0.4-4.3)
2 (18.2)
11 (12.5)
0.635
1.6 (0.3-8.2)
9 (15.5)
17 (12.1)
0.522
1.3 (0.6-3.2)
Cardiac, (%)
1 (9.1)
1 (2.8)
0 (0)
0.138
2 (4.3)
0 (0)
0.223
1 (9.1)
1 (1.1)
0.211
8.7 (0.5-150.1)
3 (5.2)
1 (0.7)
0.076
7.6 (0.8-74.5)
Pulmonary, (%)
1 (9.1)
0 (0)
1 (1.9)
0.172
1 (2.1)
1 (1.9)
>0.999
1.1 (0.07-18.2)
1 (9.1)
1 (1.1)
0.211
8.7 (0.5-150.1)
2 (3.4)
2 (1.4)
0.582
2.5 (0.3-17.9)
Vasculitis, (%)
2 (18.2)
6 (16.7)
11 (21.2)
0.867
8 (17)
11 (21.2)
0.602
0.8 (0.3-2.1)
2 (18.2)
17 (19.3)
>0.999
1 (0.2-4.7)
10 (17.2)
28 (20)
0.654
0.8 (0.4-1.9)
SDI ()
0.501
0.255
0.480
0.217
LSI ()
0.179b
0.573
0.002
0.155
SLICC damage index ()
0.170
0.088
0.169
0.045
Comparisons were done using the Chi-square tests for the categorical data while the unpaired sample -test and the one-way ANOVA test were used to compare the quantitative data between two and multiple groups, respectively, unless specified. aThe significant difference was persistent after Bonferroni correction and logistic regression. bKruskal-Wallis test was used. : number. MC: mucocutaneous; MSK: musculoskeletal; NPS: neuropsychiatric; SDI: Lupus Severity of Disease Index; LSI: Lupus Severity Index; SLICC: Systemic Lupus International Collaborating Clinics; OR: odds ratio; CI: confidence interval.
