Evaluation of Macrophage Activation Syndrome in Patients with Systemic Juvenile Idiopathic Arthritis: A Single Center Experience
Table 3
Demographic characteristics and laboratory data in children with active SJIA with and without MAS according to the 2016 MAS classification criteria.
sJIA with MAS
sJIA without MAS
value
Patients
8
24
Age at onset (years)
11.5 (3.1-15.3)
10.8 (6.4-12.8)
0.761
Gender (f/m)
5/3
9/15
0.217
Ferritin (μg/L)
3786 (2246-8577)
695 (243-2551)
0.006
Platelets (×109/L)
190 (137-272)
425 (317-498)
0.001
Fibrinogen (μmol/L)
10.3 (4.9-10.9)
18.1 (11.4-21.5)
0.008
Triglycerides (mmol/L)
3.0 (1.8-5.8)
1.3 (1.1-2.1)
0.003
ALT (U/L)
128 (20-167)
13 (9-21)
0.006
LDH (U/L)
697 (454-1153)
260 (198-321)
0.003
WBC (×109/L)
7.1 (5.5-11.4)
16.0 (9.2-23.4)
0.007
Neutrophils (×109/L)
4.0 (3.7-4.4)
12.6 (6.1-20.8)
0.002
ESR (mm/hr)
45 (34.8-81.8)
74 (50.8-96)
0.030
CRP (mg/L)
41.3 (10.8-78.9)
104.6 (38.6-134.3)
0.058
Hb (mmol/L)
7.0 (6.0-7.3)
7.0 (5.9-7.3)
0.794
Ferritin/ESR ratio
127.1 (47.6-269.7)
10.5 (4.3-38.3)
<0.001
MS score
-0.95 (-2.2–(+0.18))
- 4.7 (-5.3–(-2.5))
0.003
ALT: alanine aminotransferase; LDH: lactate dehydrogenase; WBC: white blood cells; ESR: erythrocyte sedimentation rate; CRP: C-reactive protein; Hb: hemoglobin. Values are expressed as median with interquartile range in parenthesis. values are obtained using Mann–Whitney test for comparison.
