Autoimmune Idiopathic Inflammatory Myopathies: Pharmacological Differences and Similarities by Type of Myositis and by Sociodemographic Variables

Table 1

Comparison of some sociodemographic and pharmacological variables between the types of overlap myositis and nonoverlap myositis in Colombia.

Variables	Nonoverlap myositis		Overlap myositis
		%		%
Age, median (IQR)	55.0 (41.0-65.0)		59.0 (47.0-68.0)		0.016
Women	303	65.9	173	82.0	<0.001
Comorbidities	324	70.4	211	100.0	<0.001
Arterial hypertension	154	33.5	95	45.0	0.004
Diabetes mellitus	87	18.9	52	24.6	0.089
Hypothyroidism	76	16.5	48	22.7	0.054
Rheumatoid arthritis	0	0.0	119	56.4	<0.001
Chronic pain	43	9.3	34	16.1	0.011
Infections	91	19.8	66	31.3	0.001
Pharmacotherapy	408	88.7	206	97.6	<0.001
Systemic glucocorticoids	349	75.9	178	84.4	0.013
Prednisolone	264	57.4	150	71.1	0.001
Prednisone	100	21.7	49	23.2	0.668
Dexamethasone	85	18.5	34	16.1	0.457
Methylprednisolone	27	5.9	25	11.8	0.007
Pulses	5	1.1	5	2.4	0.301
Deflazacort	29	6.3	18	8.5	0.294
Betamethasone	21	4.6	9	4.3	0.861
Hydrocortisone	8	1.7	2	0.9	0.733
Conventional DMARDs	303	65.9	194	91.9	<0.001
Azathioprine	205	44.6	122	57.8	0.001
Methotrexate	141	30.7	101	47.9	<0.001
Chloroquine	56	12.2	49	23.2	<0.001
Hydroxychloroquine	5	1.1	27	12.8	<0.001
Sulfasalazine	3	0.7	3	1.4	0.385
Leflunomide	2	0.4	3	1.4	0.182
Immunosuppressants	32	7.0	29	13.7	0.005
Mycophenolate	12	2.6	12	5.7	0.046
Cyclosporine	11	2.4	10	4.7	0.105
Cyclophosphamide	11	2.4	10	4.7	0.105
Human immunoglobulin	2	0.9	3	0.7	0.652
Biological DMARDs	9	2.0	16	7.6	<0.001
Rituximab	7	1.5	14	6.6	<0.001
Others ()^	2	0.4	2	0.9	0.594
Comedications	—	—	—	—	—
Analgesics	291	63.3	158	74.9	0.003
Antiulcer	260	56.5	153	72.5	<0.001
Antihypertensives and diuretics	188	40.9	100	47.4	0.113
Nonsteroidal anti-inflammatory drugs	186	40.4	97	46.0	0.178
Antihistamines	154	33.5	88	41.7	0.039

IQR: interquartile range; DMARD: disease-modifying antirheumatic drugs. Mann–Whitney test. Fisher’s exact test. ^Others: adalimumab, abatacept, belimumab, and certolizumab.