The Effects of Lutein and Zeaxanthin Supplementation on Brain Morphology in Older Adults: A Randomized, Controlled Trial
Table 2
Brain volume.
M (SD) in mm3
Supplement (N = 33)
Placebo (N = 14)
Overall sample (N = 47)
Pre
Post
Pre
Post
Pre
Post
Gray matter
Global
589258 (41075)
583090 (43892)
598888 (26886)
595608 (27435)
592127 (37387)
586819 (39829)
Regions-of-interest (ROIs)
Prefrontal
102435 (10156)
101378 (10354)
105206 (7147)
104517 (6733)
103260 (9372)
102313 (9460)
Orbitofrontal
23839 (2388)
23809 (2208)
23430 (1645)
23590 (1719)
23717 (2184)
23744 (2058)
Anterior cingulate
7989 (1319)
7910 (1447)
7887 (1055)
7864 (1102)
7958 (1236)
7896 (1341)
Medial temporal
27361 (2589)
27234 (2558)
27063 (2342)
27234 (2658)
27212 (2496)
27234 (2559)
Hippocampus
8681 (989)
8407 (1050)
9144 (743)
8962 (886)
8819 (939)
8572 (1027)
White matter
Global
437384 (74298)
432185 (81221)
427438 (40081)
423846 (39899)
434422 (65691)
429701 (71090)
Regions-of-interest (ROIs)
Prefrontal
84364 (8774)
83736 (10028)
83119 (7414)
82317 (7317)
83994 (8332)
83313 (9247)
Orbitofrontal
18494 (2083)
18421 (2345)
18141 (1484)
18083 (1531)
18389 (1915)
18313 (9247)
Anterior cingulate
9228 (902)
9160 (951)
9336 (696)
9294 (699)
9260 (840)
9200 (878)
Medial temporal
17092 (2499)
16955 (2736)
16803 (2039)
16961 (2015)
17006 (2353)
16957 (2521)
Lateral ventricle
33250 (15696)
35066 (16500)
28855 (11638)
30229 (12088)
31941 (14622)
33625 (15352)
White matter hypointensities
7759 (14588)
8090 (16083)
5543 (4446)
5625 (4690)
7099 (12437)
7356 (13692)
Note: All volumes are corrected for intracranial volume (ICV) and have been rounded to the nearest mm3. indicates a significant change from pre- to postintervention, , controlling for age and Clinical Dementia Rating (CDR) score.
