Correlation between Blood Activin Levels and Clinical Parameters of Type 2 Diabetes

Table 4

Associations between circulating levels of follistatin and demographic and biochemical indices within subject groups.

	Total subjects	Normal	IFG/IGT	T2D
Age	0.028	−0.041	0.399	−0.054
BMI	0.200	0.004	0.140	0.373*
Smoking	0.304**	0.162	0.226	0.413*
Fasting glucose	0.130	−0.221	0.172	0.175
HbA1c	0.100	−0.061	0.274	0.073
Fasting insulin	0.180	0.082	0.304	0.187
HOMA-IR	0.268*	0.041	0.351	0.323
AUCg	0.271*	0.071	0.411	−0.042
Crcl	0.210	−0.011	0.095	0.371*
HsCRP	0.585***	0.394*	0.642**	0.740***

BMI: body mass index; HbA1c: glycated hemoglobin; HOMA-IR: homeostasis model assessment of insulin resistance; AUCg: area under the curve for OGTT glucose levels; Crcl: creatinine clearance; HsCRP: human sensitive C-reactive protein. Data presented as univariate Pearson correlation coefficients (𝑅) value: *𝑃<0.05, **𝑃<0.01, ***𝑃<0.001. Correlations with no superscript are not significant (𝑃>0.05). Follistatin was positively correlated with HOMA-IR and AUCg among total participants only, and this was not altered after multivariate analysis for confounding factors (including age, BMI, history of smoking, history of hypertension and medication use, blood pressure parameters).