Dipeptidyl Peptidase 4 Inhibition May Facilitate Healing of Chronic Foot Ulcers in Patients with Type 2 Diabetes

Figure 2

Effects of vildagliptin on HIF-1α and VEGF in the periphery of the ulcer before and after treatment. Representative sections show immunochemistry for HIF-1α (a) (×400) and proteasome 20S (d) (×400) in ulcer specimens of control and vildagliptin patients at baseline and after 12 weeks of active treatment. Western blot analysis of HIF-1α (b) and VEGF (e) content in ulcer specimens from control and vildagliptin patients. RT-PCR analysis of HIF-1α (c) and VEGF (f) content in ulcer specimens from control and vildagliptin patients. ^∗𝑃<0.05 versus control patients. ^†𝑃<0.05 versus baseline.