Clinical Study
Dipeptidyl Peptidase 4 Inhibition May Facilitate Healing of Chronic Foot Ulcers in Patients with Type 2 Diabetes
Table 1
Baseline characteristics of study patients.
| | | Control group | Vildagliptin group | P |
| | N | 53 | 53 | | | Mean age (years) | 63 ± 15 | 64 ± 17 | NS | | Sex (M/F) | 34/19 | 35/18 | NS | | BMI | 29 ± 2.8 | 30 ± 2.1 | NS | | Diabetes duration (years) | 16 ± 6 | 17 ± 5 | NS | | Waist-to-hip ratio | 0.91 ± 0.06 | 0.92 ± 0.09 | NS | | Systolic blood pressure (mmHg) | 131 ± 18 | 129 ± 16 | NS | | Diastolic blood pressure (mmHg) | 79 ± 8 | 80 ± 7 | NS | | Heart rate (bpm) | 83 ± 26 | 84 ± 24 | NS | | Laboratory results | | | | | Glycated hemoglobin (%) | 8.0 ± 1.2 | 8.1 ± 1.3 | NS | | Plasma glucose (mg/dL) | 168 ± 33 | 170 ± 36 | NS | | Creatinine (mg/dL) | 1.1 ± 0.6 | 1.0 ± 0.8 | NS | | Colesterol (mg/dL) | 230 ± 49 | 234 ± 51 | NS | | Triglycerides (mg/dL) | 166 ± 63 | 171 ± 69 | NS | | HDL (mg/dL) | 36 ± 12 | 35 ± 11 | NS | | LDL (mg/dL) | 162 ± 23 | 165 ± 30 | NS | | Risk factors | | | | | Hypertension (%) | 32 (61) | 33 (62) | NS | | Hyperlipidemia (%) | 25 (47) | 26 (48) | NS | | CAD (%) | 22 (41) | 21 (39) | NS | | Stroke (%) | 5 (10) | 4 (7) | NS | | Previous smokers (%) | 19 (36) | 20 (38) | NS | | Active smokers (%) | 5 (10) | 6 (12) | NS | | Therapy | | | | | Insulin (%) | 14 (26) | 14 (26) | NS | | Metformin (%) | 26 (50) | 28 (52) | NS | | Sulfonylurea (%) | 11 (21) | 10 (19) | NS | | Statin (%) | 42 (80) | 43 (81) | NS | | Aspirin (%) | 34 (64) | 36 (67) | NS | | Clopidogrel (%) | 6 (11) | 7 (13) | NS | | Warfarin (%) | 4 (7 ) | 5 (10) | NS | | ACE-inhibitor or ARB (%) | 31 (60) | 30 (58) | NS | | β-blocker (%) | 14 (26) | 15 (29) | NS | | Diuretics (%) | 33 (62) | 36 (67) | NS | | Ankle-brachial index (mmHg) | 1.0 ± 0.1 | 1.0 ± 0.2 | NS | | Transcutaneous oxygen tension (mmHg) | 44.9 ± 12.1 | 44.2 ± 11.8 | NS | | Ulcer duration before treatment (days) | 122 ± 22 | 126 ± 26 | NS | | Plantar foot ulcers (%) | 32 (61) | 33 (62) | NS | | Dorsal foot ulcers (%) | 11 (21) | 10 (19) | NS | | Lateral foot ulcers (%) | 10 (19) | 10 (19) | NS | | Baseline wound area (cm2) | 4.1 ± 1.2 | 4.3 ± 1.5 | NS | | Off-loading methods | | | | | Accommodative dressing (%) | 30 (60) | 30 (60) | NS | | Healing shoe (%) | 3 (6) | 5 (9) | NS | | Walking splint (%) | 1 (2) | 1 (2) | NS |
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Data are means ± SD or (%).
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