Plasma Lactate Levels Increase during Hyperinsulinemic Euglycemic Clamp and Oral Glucose Tolerance Test

Figure 5

Lactate levels during OGTT according to glucose tolerance. OGTT was based on 75 g oral glucose tolerance tested over 120 min. Normal glucose tolerance (NGT) is based on glucose levels less than or equal to 140 mg/dL at time 120 min, and impaired glucose tolerance (IGT) is based on glucose levels 140–200 mg/dL at time 120 min. Plasma lactate was measured as shown in Study Subjects. (a) showed significantly higher levels of lactate among participants with IGT. The difference continued throughout the period of OGTT. (b) showed mean total lactate levels during OGTT. The cumulative lactate level among participants with IGT was significantly higher than those participants with NGT ().

(a)

(b)