VDR Polymorphisms in Autoimmune Connective Tissue Diseases: Focus on Italian Population
Table 1
Genotype distribution of VDR polymorphisms in SLE, pSS, RA, and HCs.
rs2228570 C > T Fok1
TOT
CC
CT
TT
a
OR (95% CI)
HCs
246
103
120
23
SLE
308
121
139
48
0.029
1.79 (1.05-3.05)
pSS
195
88
83
24
0.32
1.36 (0.74-1.49)
RA
192
87
87
18
1
1 (0.52-1.92)
rs7975232 T > G Apa1
TOT
TT
TG
GG
a
OR (95% CI)
HCs
239
82
124
33
SLE
301
104
129
68
0.009
1.82 (1.15-2.87)
pSS
195
55
99
41
0.046
1.66 (1.01-2.75)
RA
192
52
98
42
0.028
1.75 (1.06-2.89)
rs731236 A > G Taq1
TOT
AA
AG
GG
a
OR (95% CI)
HCs
242
75
127
40
SLE
300
113
138
49
1
0.99 (0.62-1.56)
pSS
195
74
94
27
0.44
0.81 (1.48-1.38)
RA
192
80
93
19
0.045
0.55 (0.31-0.99)
a value represents the analysis based on the recessive model (homozygous variant genotypes vs. others). HCs: healthy controls; SLE: systemic lupus erythematosus; pSS: primary Sjogren’s syndrome; RA: rheumatoid arthritis; OR: odds ratio; CI: confident interval. Significant associations are reported in italic.
