Lung Cancer Risk and Genetic Polymorphisms in DNA Repair Pathways: A Meta-Analysis

Figure 1

Meta-analysis of 8 studies (5 Caucasian studies and 3 non-Caucasian studies) of lung cancer and theXPA G23A polymorphism (GG versus AA). The center of a box and the horizontal line (logarithm) indicate the odds ratio (OR) and the 95% confidence interval (CI) in each study, with the areas of the boxes representing the weight of each study. The summary OR based on random effects model is represented by the middle of a diamond whose width indicated the 95% CI. The summary OR is shown by the dotted vertical line. Statistical heterogeneity between studies was assessed with Cochran 𝑃=.015 test (𝑄 = 7.86, (𝑃=.040)). Summary: 𝑃=.010 (95% CI = 0.61–0.94).