Lung Cancer Risk and Genetic Polymorphisms in DNA Repair Pathways: A Meta-Analysis

Table 2

Genetic polymorphisms in the BER pathway and lung cancer risk: OGG1 Ser326Cys polymorphism.

Author, published year (reference no.)	Ethnicity	No. of Cases/Controls	Source of controls	OR (95% CI)∗		Quality control of genotyping
				Ser/Cys	Cys/Cys
Sugimura et al., 1999 [16]	Asian	241/197	Hospital	0.80; (0.52–1.21)	1.13; (0.63–2.02)	Sequencing
Wikman et al., 2000 [17]	Caucasian	105/105	Hospital	0.66; (0.37–1.17)	2.20; (0.41–11.8)	Sequencing
Ito et al., 2002 [18]	Asian	138/240	Hospital	1.02; (0.63–1.67)	0.85; (0.46–1.56)	None
Sunaga et al., 2002 [19]	Asian	198/152	Hospital	1.49; (0.91–2.43)	0.98; (0.54–1.77)	None
Le Marchand et al., 2002 [20]	Admixed population	298/405	Population	0.90; (0.65–1.26)	1.76; (1.15–2.71)	Sequencing
Lan et al., 2004 [21]	Asian	118/109	Population	1.96; (1.10– 3.48)	1.84; (0.83–4.06)	None
Park et al., 2004 [22]	Mostly composed of Caucasians	179/350	Screening	1.89; (1.27–2.80)	4.10; (1.65–10.2)	Sequencing
Vogel et al., 2004 [23]	Caucasian	256/269	Population	1.09; (0.75– 1.60)	0.78; (0.35–1.72)	Replication (random samples)
Liang et al., 2005 [24]‡	Asian	227/227	Hospital	0.94; (0.63–1.41)	0.98; (0.33–2.87)	Sequencing
Hung et al., 2005 [25]	Mostly composed of Caucasians	2,155/2,163	Hospital	0.90; (0.79–1.03)	1.15; (0.84–1.57)	Replication (random samples)
Zienolddiny et al., 2006 [26]‡	Caucasian	326/386	Population	0.91; (0.64–1.29)	0.63; (0.40–0.97)	Replication (all samples)
Matullo et al., 2006 [27]	Caucasian	116/1094	Population	1.26; (0.83– 1.91)	0.82; (0.21–2.33)	Replication (random samples)
Kohno et al., 2006 [28]	Asian	1097/394	Hospital	1.24; (0.94–1.63)	1.43; (1.02–2.01)	None
Sørensen et al., 2006 [29]	Caucasian	431/796	Population	1.04; (0.80–1.35)	1.18; (0.63–2.21)	Replication (random samples)
De Ruyck et al., 2007 [30]	Caucasian	110/110	Hospital	0.58; (0.33–1.02)	0.61; (0.13–2.82)	None
Karahlil et al., 2008 [31]	Turkish	165/250	Hospital	0.82; (0.54–1.24)	0.65; (0.32–1.29)	None
Miyaishi et al., 2009 [32]	Asian	108/121	Hospital	1.47; (0.79–2.73)	1.34; (0.65–2.77)	None
Chang et al., 2009 [33]	Latino	112/296	Population	0.91; (0.56–1.47)	1.05; (0.45–2.32)	Replication (random samples)
Chang et al., 2009 [33]	African-American	254/280	Population	1.32; (0.89–1.98)	0.89; (0.25–3.00)	Replication (random samples)
Summary∗∗	No. of populations					Cochran 𝑄 test for heterogeneity
						Ser/Cys	Cys/Cys
All	17	6,181/7,331		1.04; (0.94–1.23)	1.22; (1.02–1.45)	0.004	0.220
Caucasian (mostly composed of Caucasians)	7	3,352/4,887		1.02; (0.81–1.29)	1.24; (0.84–1.83)	0.004	0.133
Asian	6	1,900/1,213		1.23; (0.97–1.55)	1.24; (1.00–1.55)†	0.159	0.572

∗Crude odds ratio and 95% confidence interval.
∗∗Based on random effects model.
^†𝑃=.052.
‡Excluded from the meta-analysis because genotype distribution of control population was not in Hardy-Weinberg equilibrium. NA, not available.