Lung Cancer Risk and Genetic Polymorphisms in DNA Repair Pathways: A Meta-Analysis

Table 6

Genetic polymorphisms in the NER pathway and lung cancer risk: XPA G23A polymorphism.

Author, published year (reference no.)	Ethnicity	No. of Cases /controls	Source of controls	OR (95% CI)256/269		Quality control of genotyping
				G/A	G/G
Park et al., 2002 [50]	Asian	248/276	Population	1.00; (0.62–1.62)	0.62; (0.35–1.10)	Sequencing
Wu et al., 2003 [51]	Caucasian	110/109	Population	0.65; (0.48–0.87)	0.74; (0.55–1.01)	None
Wu et al., 2003 [51]	Mexican-American	∗∗	Population	0.31; (0.09–1.00)	0.40; (0.13–1.25)	None
Wu et al., 2003 [51]	African-American	∗	Population	0.54; (0.16–1.68)	0.49; (0.15–1.49)	None
Popanda et al., 2004 [42]	Caucasian	∗∗	Hospital	0.77; (0.48–1.21)	0.82; (0.52–1.30)	Replication (random samples)
Vogel et al., 2005 [52]	Caucasian	𝑄	Population	0.78; (0.41–1.49)	0.57; (0.30–1.06)	None
Zienolddiny et al., 2006 [26]	Caucasian	𝑄	Population	0.87; (0.48–1.57)	1.41; (0.79–2.52)	Replication (all samples)
De Ruyck et al., 2007 [30]	Caucasian	𝑃=.35	Hospital	1.00; (0.34–2.92)	1.02; (0.34–3.03)	None
SummaryOR=0.76	No. of populations					Cochran Q test for heterogeneity
						G/A	G/G
All	8	2,025/1,991		0.74; (0.61–0.90)	0.76; (0.61–0.94)	0.640	0.345
Caucasian	5	1,639/1,692		0.73; (0.59–0.90)	0.83; (0.64–1.08)	0.855	0.266

Crude odds ratio and 95% confidence interval.
𝑃=.079 Based on random effects model.