Review on Medical Applications of Manganese Oxide (Mn²⁺, Mn³⁺, and Mn⁴⁺) Magnetic Nanoparticles

Figure 14

(a) In vitro T1-MR imaging of PMIDA NPs with different concentrations of Mn²⁺ (0.025, 0.05, 0.1, 0.2, and 0.4 mM) was performed; (b) linear fitting of Mn²⁺ concentration and 1/T₁ of PMIDA NPs; (c) corresponding normalized signal intensity enhancement of the T1-weighted MR signals in the 4T₁ tumor section; and (d) in vivo MR images of 4T₁ tumor-bearing mice pre- and post-intravenous injection of PMIDA NPs dispersions (reprinted with permission from [155], Elsevier).

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