7 pediatric patients aged 1.3–15.8 y with serious burns (≥20% of BSA) tolerating enteral feedings
Randomized double-blind crossover
Enteral Gln; EN (Pediasure and/or Jevity) with Gln (0.6 g/kg/d) replacing 20% of essential and nonessential AA for 48–72 h ()
Isocaloric isonitrogenous standard EN (Pediasure and/or Jevity) supplemented with modular protein (Promod) for 48–72 h ()
Whole-body protein kinetics (IV infusion of L-[1–13C]Leu, NaH13CO3) after 48 h enteral feeding (fed state), nitrogen balance, plasma Gln concentrations
Decreased Leu flux and Leu oxidation rate, no differences in net balance of Leu accretion into proteins, nitrogen balance or plasma Gln concentrations, well tolerated
36 trauma patients aged 15–60 y ( severe trauma; burn BSA 30–60%)
Randomized controlled
Enteral Gln; exclusive EN enriched with Arg, Gln, omega-3 fatty acids (Neomune) started on postinjury d-2 until d-10 (≤0.15 g/kg/d Gln) ()
Standard exclusive EN for trauma patients (traumacal) started on postinjury d-2 until d-10 (≤0.07 g/kg/d Gln) ()
Biochemical and immune parameters after 10 d supplementation, morbidity, and mortality
No differences in immunologic or biochemical parameters (except increased serum total protein, decreased serum triglycerides), no significant differences in nitrogen balance, LOS in ICU/hospital, d to wean off ventilator, or mortality, well tolerated