Associations of Plasma BDNF and BDNF Gene Polymorphism with Cardiometabolic Parameters in Thai Children: A Pilot Study
Table 3
Logistic regression analysis of anthropometric-cardiometabolic and hematological variables associated with the single nucleotide polymorphisms BDNF G196A and C270T (N = 469).
Variables†
BDNF G196A
-value
BDNF C270T
value
Odds ratio (95% CI)
Odds ratio (95% CI)
Weight (kg)
0.990 (0.979–1.009)
0.145
1.011 (0.997–1.026)
0.132
BMI z-score
0.913 (0.885–1.025)
0.208
1.100 (0.959–1.262)
0.175
WC (cm)
0.992 (0.979–1.005)
0.224
1.011 (0.996–1.026)
0.149
Systolic BP (mmHg)
0.984 (0.971–0.998)
1.013 (0.998–1.030)
0.093
Diastolic BP (mmHg)
0.982 (0.963–1.000)
0.054
1.013 (0.992–1.033)
0.227
Glucose (mg/dL)
1.014 (0.985–1.025)
0.713
1.009 (0.975–1.043)
0.613
TC (mg/dL)
0.998 (0.991–1.008)
0.638
0.995 (0.988–1.002)
0.159
TG (mg/dL)
0.997 (0.991–1.005)
0.169
1.003 (0.997–1.009)
0.347
LDL-C (mg/dL)
1.009 (0.997–1.016)
0.232
0.997 (0.989–1.005)
0.501
HDL-C (mg/dL)
0.998 (0.981–1.015)
0.680
0.994 (0.989–1.005)
0.195
Non-HDL-C (mg/dL)
0.997 (0.991–1.007)
0.510
0.998 (0.990–1.006)
0.626
TyG index
0.680 (0.427–1.083)
0.104
1.405 (0.834–2.367)
0.201
RBC count (×1012/L)
0.822 (0.528–1.278)
0.383
0.923 (0.553–1.541)
0.761
WBC count (×109/L)
0.998 (0.987–1.009)
0.724
0.995 (0.983–1.008)
0.471
Platelet count (×109/L)
1.180 (0.827–1.686)
0.362
1.036 (0.697–1.540)
0.862
BDNF (ng/mL)
0.974 (0.941–1.008)
0.130
1.015 (0.980–1.022)
0.347
†Adjusted for the covariates age and gender, when SNP BDNF G196A (the absence vs. the presence of the A allele) or SNP BDNF C270T (the absence vs. the presence of the T allele) was used as a dependent variable. .
