Differences in In Vitro Disintegration Time among Canadian Brand and Generic Bisphosphonates

Table 2

Comparisons of mean disintegration times among brand and generic bisphosphonates.

Bisphosphonate tablet comparison	Mean disintegration time difference in seconds	95% CI^a
Brand alendronate—brand alendronate plus vitamin D	−231*	264, 197
Brand alendronate—risedronate	46*	13, 80
Brand alendronate—Apo-alendronate	122*	88, 155
Brand alendronate—Novo-alendronate	135*	100, 169
Brand alendronate plus vitamin D—risedronate	277*	243, 310
Brand alendronate plus vitamin D—Apo-alendronate	352*	319, 386
Brand alendronate plus vitamin D—Novo-alendronate	365*	331, 400
Risedronate—Apo-alendronate	76*	42, 109
Risedronate—Novo-alendronate	89*	54, 123
Apo-alendronate—Novo-alendronate	13	−20, 46

95% CI = 95% confidence interval; significant disintegration time difference between groups at .