Impact of Recipient and Donor Obesity Match on the Outcomes of Liver Transplantation: All Matches Are Not Perfect

Table 3

(a) Multivariable regression models of patient survival after liver transplantation. (b) Multivariable regression models of graft survival after liver transplantation. (c) Multivariable regression models of primary and secondary outcomes after liver transplantation.

(a)

	30-day survival ( = 40,478)			1-year survival (if they survived to 30 days; = 39,227)			5-year survival (if they survived to 1 year; = 36,020)
	HR	95% CI		HR	95% CI		HR	95% CI
R nonobese, D nonobese	Ref.			Ref.			Ref.
R nonobese, D obese	1.02	(0.86, 1.21)	0.823	0.91	(0.82, 1.01)	0.076	1.03	(0.94, 1.13)	0.493
R obese, D nonobese	1.09	(0.94, 1.25)	0.247	0.86	(0.78, 0.94)	0.001	0.92	(0.85, 1.00)	0.039
R obese, D obese	1.38	(1.16, 1.65)	<0.001	0.84	(0.74, 0.95)	0.007	0.90	(0.81, 1.02)	0.088

Cox proportional hazards model. Statistically significant difference relative to “R nonobese, D obese” group. Statistically significant difference relative to “R obese, D nonobese” group.
All models are adjusted for D and R gender, D and R race, D and R age, R diagnosis, D and R diabetes history, D and R serum creatinine, D and R bilirubin, R INR, albumin, and MELD score at LT, and D SGOT and SGPT, acute rejection, PVT, and cold ischemia time. LT = liver transplantation, R = recipient, D = donor, HR = hazard ratio, and CI = confidence interval.

(b)

	30-day survival ( = 40,478)			1-year survival ( = 38,556)			5-year survival ( = 34,796)
	HR	95% CI		HR	95% CI		HR	95% CI
R nonobese, D nonobese	Ref.			Ref.			Ref.
R nonobese, D obese	0.97	(0.85, 1.11)	0.703	0.89	(0.81, 0.98)	0.019	1.00	(0.92, 1.09)	0.980
R obese, D nonobese	1.14	(1.02, 1.28)	0.018	0.86	(0.79, 0.93)	<0.001	0.93	(0.86, 1.01)	0.077
R obese, D obese	1.27	(1.09, 1.46)	0.002	0.83	(0.74, 0.93)	0.002	0.90	(0.81, 1.01)	0.071

Cox proportional hazards model. Statistically significant difference relative to “R nonobese, D obese” group. All models are adjusted for D and R gender, D and R race, D and R age, R diagnosis, D and R diabetes history, D and R serum creatinine, D and R bilirubin, R INR, albumin, and MELD score at LT, and D SGOT and SGPT, acute rejection, PVT, and cold ischemia time.
LT = liver transplantation, R = recipient, D = donor, HR = hazard ratio, and CI = confidence interval.

(c)

	Overall patient survival ( = 40,478)			Days of hospital stay post-LT ( = 39,831)			Retransplantation ( = 39,401)
	HR	95% CI			95% CI		SHR	95% CI
R nonobese, D nonobese	Ref.			Ref.			Ref.
R nonobese, D obese	0.98	(0.92, 1.04)	0.547	−0.58	(−1.22, 0.05)	0.071	0.81	(0.69, 0.94)	0.006
R obese, D nonobese	0.91	(0.86, 0.96)	<0.001	−0.64	(−1.18, −0.10)	0.021	1.11	(0.98, 1.26)	0.096
R obese, D obese	0.93	(0.86, 1.00)	0.042	−0.93	(−1.68, −0.17)	0.016	0.91	(0.76, 1.09)	0.314

Cox proportional hazards model. Ordinary least-squares regression model. Competing-risks regression model with mortality as a competing risk. Statistically significant difference relative to “R nonobese, D obese” group. Statistically significant difference relative to “R obese, D nonobese” group. All models are adjusted for D and R gender, D and R race, D and R age, R diagnosis, D and R diabetes history, D and R serum creatinine, D and R bilirubin, R INR, albumin, and MELD score at LT, and D SGOT and SGPT, acute rejection, PVT, and cold ischemia time. LT = liver transplantation, R = recipient, D = donor, HR = hazard ratio, = unstandardized coefficient, SHR = subhazard ratio, and CI = confidence interval.