Mediators of Inflammation / 2010 / Article / Tab 2 / Review Article
DAMPening Inflammation by Modulating TLR Signalling Table 2 Targeted deletion of DAMPs protects from experimental disease . Mice which do not express certain DAMPs exhibit reduced symptoms of inflammatory disease or tumor metastasis in vivo .
DAMP Disease Model Effect of deletion Refs Biglycan Renal inflammation (unilateral ureteral obstruction) Reduced kidney damage [87 ] Sepsis (LPS or zymosan) Protected from lethality [23 , 87 ] FNEDA Atherosclerosis (Apo E deficient, high fat diet) Reduced lesion size, number and macrophage infiltration [139 ] MRP8/MRP14 Abdominal sepsis (E. coli ) Reduced bacterial dissemination, systemic inflammation, liver damage [140 ] Arterial injury (femoral wire insertion) Reduced inflammatory cell infiltration and neotintimal formation [141 ] Atherosclerosis (Apo E deficient, high fat diet) Attenuated atherosclerotic lesions and macrophage accumulation in plaques [141 ] Cerebral ischemia (cerebral artery occlusion) Reduced lesion volume, brain swelling and inflammatory cell infiltration [142 ] Lethal sepsis (LPS ) Protects from lethality [143 ] Vasculitis (cytokine induced) Reduced neutrophil accumulation and lesion severity [141 ] Tenascin-C Destructive joint inflammation (antigen induced arthritis) Protected from joint erosion and tissue destruction [24 ] Tumorigenesis (cross with MMTV/PyV mice) Induced smaller tumor nests [144 ]