Stimulation of MMP-1 and CCL2 by NAMPT in PDL Cells
Figure 4
Regulation of NAMPT and COX2 expressions by IL-1β. NAMPT expression in PDL cells from 6 donors in response to IL-1β (1 ng/mL) at 1 d and 3 d (a). Stimulation of NAMPT expression in PDL cells from 3 donors by various concentrations of IL-1β (0.2, 1.0, and 5.0 ng/mL) at 1 d (b). NAMPT protein synthesis in PDL cells in the presence and absence of IL-1β and P. gingivalis at 3 d. Images from one representative donor are shown (c). COX2 expression in PDL cells from 6 donors in response to IL-1β (1 ng/mL) at 1 d and 3 d (d). All experiments were performed in triplicate and repeated at least twice. Mean ± SEM; *significantly () different from IL-1β-untreated cells (control).
