Mediators of Inflammation

Research Article

Stimulation of MMP-1 and CCL2 by NAMPT in PDL Cells

Table 1

Regulation of gene expression by NAMPT, as analyzed by microarray.


Gene	LogFC	adj. value

EGR1	2.184	0.008
MMP-1	1.545	0.010
SYT7	1.443	0.010
ITPKA	1.292	0.010
CCL2	1.150	0.028
NTM	1.114	0.028
IGF2BP3	1.040	0.020
NRP1	1.024	0.010
KCTD12	1.019	0.048
HSPB3	−1.035	0.030
TM4SF20	−1.164	0.028
RGS4	−1.397	0.025

Effect of NAMPT on gene expression of PDL cells from 3 donors at 1 d. Only genes with statistically significant (FDR < 5%) (upregulation by at least 2-fold) or (downregulation by at least 50%) were considered. Abbreviations: EGR1: early growth response 1; MMP-1: matrix metalloproteinase-1; SYT7: synaptotagmin 7; ITPKA: inositol 1,4,5-trisphosphate 3-kinase a; CCL2: chemokine, cc motif, ligand 2; NTM: neurotrimin; IGF2BP3: insulin-like growth factor 2 mRNA-binding protein 3; NRP1: neuropilin 1; KCTD12: potassium channel tetramerization domain-containing protein 12; HSPB3: heat-shock 27-kD protein 3; TM4SF20: transmembrane 4 L six family member 20; RGS4: regulator of G protein signaling 4.