Stimulation of MMP-1 and CCL2 by NAMPT in PDL Cells

Table 2

Upregulation of gene expression by NAMPT, as analyzed by real-time PCR.

Gene	Fold change; (mean)	SD	SEM	𝑃 value
EGR1	2.422	2.306	0.421	<0.001
MMP-1	3.781	3.116	0.569	<0.001
SYT7	4.575	7.947	1.451	<0.001
ITPKA	2.764	3.182	0.581	0.001
CCL2	2.285	1.346	0.246	<0.001
NTM	2.124	2.460	0.449	<0.001
IGF2BP3	1.897	0.970	0.177	<0.001
NRP1	1.653	1.658	0.303	<0.001
KCTD12	1.713	0.958	0.175	0.095

Effect of NAMPT on gene expression of PDL cells from 10 donors at 1 d. Abbreviations: EGR1: early growth response 1; MMP-1: matrix metalloproteinase-1; SYT7: synaptotagmin 7; ITPKA: inositol 1,4,5-trisphosphate 3-kinase a; CCL2: chemokine, cc motif, ligand 2; NTM: neurotrimin; IGF2BP3: insulin-like growth factor 2 mRNA-binding protein 3; NRP1: neuropilin 1; KCTD12: potassium channel tetramerization domain-containing protein 12.