Predictive Power of Cognitive Biomarkers in Neurodegenerative Disease Drug Development: Utility of the P300 Event-Related Potential

Figure 3

Schematic of the ERP P300 waveform in the progression of AD. Shown is a representative ERP waveform for neurotypical brain activity and normal cognition (b). A characteristic response is detected 300 ms after presentation of stimuli (P300). Early in disease onset, and usually prior to the diagnosis of AD, neural network communication is disrupted, leading to impaired brain connectivity and impaired cognition. This change in cognition can be detected as a change in the peak and/or latency (time to onset of peak) of the P300 response to stimuli (c).

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