Resveratrol Regulates Antioxidant Status, Inhibits Cytokine Expression and Restricts Apoptosis in Carbon Tetrachloride Induced Rat Hepatic Injury

Table 2

Effect of resveratrol treatment on the development of microscopic hepatocyte nodules induced by CCl₄ in male Wistar rats.

Groups	No. of rats with nodules/total rats	Nodule incidence (%)	Total no. of nodules	Average no. of nodules/nodule-bearing liver (nodule multiplicity)
B	10/10	100	246	24.6±2.4
C	6/10	60*	65	10.8±1.3^∗∗
D	3/10	30**	21	7±1.6^∗∗#

Group B, CCl₄-administered rats; group C, resveratrol-(100 mg/kg) treated rats; group D, resveratrol-(200 mg/kg) treated rats.
Results are mean ± S.E.M for 10 animals; One way ANOVA followed by Dunnett’s multiple comparison test.
^∗𝑃<0.05 and ^∗∗𝑃<0.01 as compared with group B.
^#𝑃<0.05 as compared with group C.
Animals from group A did not show visible hepatocyte nodules.