The Role of the Reactive Oxygen Species and Oxidative Stress in the Pathomechanism of the Age-Related Ocular Diseases and Other Pathologies of the Anterior and Posterior Eye Segments in Adults

<div>Schematic overview of the ROS influence on the development of early and advanced forms of age-related macular degeneration. PUFA, polyunsaturated fatty acid; A2E, a component of retinal pigmented epithelial cell (RPE) lipofuscin; ROS, reactive oxygen species; mtDNA, mitochondrial deoxyribonucleic acid; ECM, extracellular matrix; PECAM-1, platelet endothelial cell adhesion molecule; VEGF, vascular endothelial growth factor; SD, soft drusen; GA/AMD, geographic atrophy/age-related macular degeneration; CNV/AMD, choroidal neovascularization/age-related macular degeneration.</div>

Oxidative Medicine and Cellular Longevity

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Figure 4: The Role of the Reactive Oxygen Species and Oxidative Stress in the Pathomechanism of the Age-Related Ocular Diseases and Other Pathologies of the Anterior and Posterior Eye Segments in Adults 

Figure 4 | The Role of the Reactive Oxygen Species and Oxidative Stress in the Pathomechanism of the Age-Related Ocular Diseases and Other Pathologies of the Anterior and Posterior Eye Segments in Adults 