BACE1 Inhibition Utilizing Organic Compounds Holds Promise as a Potential Treatment for Alzheimer’s and Parkinson’s Diseases

Figure 2

Interaction types among residues within the BACE1 active site and (a) ponciretin, (b) danthron, (c) chrysophanol, (d) N-p-coumaroyltyramine, and (e) DB07206. Left and right images present interactions before and after MD simulations, respectively. BACE1, β-site amyloid precursor protein cleaving enzyme 1; DB07206, 6-[2-(1H-INDOL-6-YL)ETHYL]PYRIDIN-2-AMINE; MD, molecular dynamics.

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